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I am so sorry to hear this....... must be a complete nightmare for you and your wife. As the vet has covered all the tests and health checks (I am guessing, diabetes was among them). He has no infection etc... then perhaps it is behavioural?
Perhaps you could try getting in touch with a Samoyed rescue or breed club. They may have heard of this?
Otherwise, he is young...... perhaps it's 'teenage angst'.......? But the above would probably be able to advise you.
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